Manchester City defeated Brentford 3-0, closing the gap on Premier League leaders Arsenal. Liverpool drew with Chelsea, while other key Premier League results impacted European qualification hopes.
Southampton secured a 1-0 victory against Fulham with a late penalty, making them the first non-Premier League club to reach the FA Cup quarter-finals this season.
Manchester City's Erling Haaland achieved the feat in 111 games, 13 fewer than the previous fastest centurion Alan Shearer.
Erling Haaland took his league tally this season to 11 in eight games with both goals in City's 2-0 home win over Everton -- a result that temporarily put City above Arsenal on goals scored.
Arsenal's Premier League title prospects were enhanced without them even kicking a ball on Wednesday as their closest challengers Manchester City and Aston Villa both dropped points.
Arsenal maintained control of the Premier League title race as they chiselled out a nervy 2-1 win over London rivals Chelsea to open up a five-point lead at the top of the table on Sunday.
IMAGES from the EPL matches played on Sunday
Arsenal re-established their five-point lead at the top of the Premier League with a 2-0 home win against Brentford on Wednesday and for the second evening running the goals flowed as Aston Villa won 4-3 in a thriller at Brighton and Hove Albion.
Fulham held visitors Manchester United to a 1-1 draw in the Premier League on Sunday.
IMAGES from the Premier League matches played on Sunday
Manchester City's Erling Haaland became the fastest player to reach 100 Premier League goals to ignite their charge on Tuesday.
Goals from Pedro Neto and Enzo Fernandez earned Chelsea a 2-0 victory at lowly Burnley on Saturday, a win that moved the Blues within three points of Premier League leaders Arsenal.
A controversial statue of the late pop star Michael Jackson will be removed from outside Fulham's Craven Cottage ground after fans complained it made the Premier League club look like a laughing stock.
A deflected late strike from Lisandro Martinez earned Manchester United a much-needed 1-0 victory at Fulham in the Premier League on Sunday.
Manchester United and Fulham served up a frantic 2-2 draw at Craven Cottage on Sunday while Newcastle United stunned Aston Villa 6-0 with a hat-trick from Andy Carroll on another dramatic day of Premier League action.
Arsenal closed the gap on leaders Liverpool with a 2-1 Premier League victory at Nottingham Forest
Images from Thursday's action in the Premier League.
Amad Diallo struck a late equaliser as Manchester United made a mockery of their recent form to hold Premier League leaders Liverpool
Harry Kane became Tottenham Hotspur's joint all-time record goal-scorer with the winner in his side's 1-0 victory at Fulham in the Premier League on Monday.
Fulham's abject season reached a new low as third-tier Sheffield United snatched a last-gasp winner in extra time to dump the Premier League side out of the FA Cup 1-0 in a fourth round replay on Tuesday.
Manchester City took another decisive step toward an unprecedented fourth successive Premier League title with a 4-0 demolition of Fulham.
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Images from Saturday's action in the Premier League.
Italy suffered a serious blow ahead of next month's World Cup when midfielder Riccardo Montolivo broke his leg during a warm-up game against Ireland at Craven Cottage on Saturday.
Wayne Rooney's hot scoring streak continued on Saturday as he fired Manchester United 10 points clear in the Premier League title race with the only goal in a 1-0 victory at Fulham.
Chelsea's Joao Felix endured a nightmare debut when he was sent off in a 2-1 Premier League defeat at local rivals Fulham.
All the action from soccer matches played in Europe on Monday.
Arsenal displayed their typical end-of-season resilience without even playing that well to win 1-0 at Fulham in the Premier League on Saturday and strengthen their chances of a Champions League spot next season.
Liverpool's surge towards a first league title since 1990 continued on Wednesday when they beat Fulham 3-2 with a last-minute penalty while Arsenal's challenge took a knock after a 0-0 home draw against Manchester United.
Fulham striker Hugo Rodallega headed the decisive goal to seal a 2-1 win over Newcastle United in an absorbing Premier League match at Craven Cottage on Monday.
Manchester City and Chelsea both secured their Champions League places with victories on the final day of the English Premier League season and Newcastle United joined them despite stumbling to a last-day defeat.
Uruguayan striker Luis Suarez was banned for one match and fined 20,000 pounds by the English FA on Wednesday for making an offensive gesture to Fulham fans after Liverpool lost a Premier League match at Craven Cottage earlier this month.
Clint Dempsey pounced for an 85th-minute winner as Fulham beat Liverpool 1-0 in a dramatic Premier League match at Craven Cottage on Monday after a rare mistake from keeper Pepe Reina.
Bobby Zamora struck twice as Fulham thrashed League Two Port Vale 6-0 on Wednesday to reach the third round of the English League Cup.
Andy Carroll helped himself to a hat-trick as Newcastle United stunned Aston Villa 6-0 to mark a memorable home return to the Premier League on Sunday.
Images from Saturday's FA Cup quarter-finals.
Norway defender John Arne Riise completed his move from AS Roma to Fulham on Wednesday, saying he was delighted to be back in the Premier League and looking forward to joining his brother Bjorn Helge at Craven Cottage.
Portsmouth made light of their financial woes to reach the FA Cup semi-finals with a 2-0 win over Birmingham City on Saturday, Frederic Piquionne scoring twice to give their long-suffering fans something to cheer. In the day's other sixth round tie Fulham, bidding to reach the FA Cup final for the first time since 1975, played out a 0-0 draw with London rivals Tottenham Hotspur at Craven Cottage.
Fulham crushed Premier League rivals Tottenham Hotspur 4-0, 10-man Arsenal scraped a 2-1 win over League One Huddersfield and big-spending Manchester City drew 1-1 with Notts County in the FA Cup fourth round on Sunday.
Manchester United and Chelsea cruised into the FA Cup semi-finals with comfortable away wins at Fulham and Coventry City respectively on Saturday. Carlos Tevez scored twice and Wayne Rooney and Park Ji-sung also struck as United turned on the style at Craven Cottage, while goals from Didier Drogba and Alex made it six wins out of six since new manager Guus Hiddink arrived at Chelsea.